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When you join the UMass Chan Medical School team, you join us in advancing together to improve the health and well-being of our diverse communities throughout Massachusetts and across the US and the world. Together, we lead in education, research, health care delivery, and public service. Your life’s work is more than a career. It’s an expression of your passion, intellect, skill, and drive. UMass Chan's commitment to excellence, innovation, competitive benefits, and work-life integration will allow you to build a professionally rewarding career as we work together to better or improve the health of people around the globe.
Development of genome editing approaches for neurological disorders.
The Wolfe laboratory will be filling a postdoctoral position to develop improved genome editing reagents and approaches for Rett Syndrome and other neurological disorders with the goal of translating these reagents to clinical trials. This project will focus on:
1) The development of prime editing reagents with high activity and specificity for correction of common mutations in MECP2 associated with Rett Syndrome.
2) The utilization of unbiased genome-wide techniques for assessing off-target events and other genomic alterations potentially associated with genome editing.
3) The translation of the developed genome editing reagents to clinical application through in vivo safety and efficacy studies in relevant mouse models.
These studies will expose the successful candidate to cutting-edge prime editor engineering approaches and the delivery of these reagents in vivo via lipid nanoparticles. The successful candidate will also learn cutting edge deep-sequencing approaches to evaluate off-target editing within the genome. They will have the opportunity to participate in meetings/conferences associated with genome editing and gene therapy, which will broaden their exposure to cutting edge research within the field.
Candidates should have a Ph.D. in biology, biochemistry, chemistry or a related biomedical science. In addition, the potential candidate must have strong oral and written communication skills and be eager to present research results at national meetings. Prior experience with genome editing systems, cell culture, and deep-sequencing technologies is advantageous, but not required.
Applicants should send a letter (via email) describing their current research activities and their interest in this position, a CV (including publications) and contact information for three references, including your Ph.D. advisor.
Address letters to Scot Wolfe (scot.wolfe@umassmed.edu).
University of Massachusetts Chan Medical School
Department of Molecular, Cell and Cancer Biology
364 Plantation Street, LRB Room 619
Worcester, MA 01605
Further details about the Wolfe laboratory and the positions that are available can be found at https://www.umassmed.edu/Wolfe-Lab/
Posting Disclaimer:
This job posting outlines the primary responsibilities and qualifications for the role but is not intended to be an exhaustive list.
Duties and expectations may evolve in response to the needs of the department and the broader institution.
In alignment with our commitment to pay transparency, the base salary range for this position is listed above (exclusive of benefits and retirement).
At UMass Chan Medical School, final base salary offers are determined based on a combination of factors, including your skills, education, and relevant experience.
We also consider internal equity to ensure fair and consistent compensation across our teams.
Please note that the range provided reflects the full base salary range for this position. Offers are typically made within the midrange to allow for future growth and development within the role.
In addition to base pay, UMass Chan offers a comprehensive Total Rewards package, which includes paid time off, medical, dental, and vision coverage, and participation in a 401(a)-retirement plan, with the option to contribute to a voluntary 403(b) plan.
UMass Chan welcomes all qualified applicants and complies with all state and federal anti-discrimination laws.
