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GENERAL SUMMARY OF POSITION: 

R&D Scientist II is responsible for initiating and executing all preclinical scientific research and/or development strategies for monoclonal antibodies. Leads a team to the successful execution of departmental projects and achievement of departmental goals. Investigates the feasibility of applying a wide variety of scientific principles and concepts to potential inventions, products and problems.  Plans and executes laboratory research. 

MAJOR RESPONSIBILITIES:

• Develops methods for producing antigens required for immunizing HuMAb mice.
• Immunizes mice and screen hybridomas for reactivity with desired antigens.
• Develops and implements in vitro assays to detect and measure biologic activities of all monoclonal antibodies.
• Designs and implements strategies for selection of lead candidate antibodies and antibody conjugates.
• Develops small animal models of disease. Ensures the completion of all in vitro and in vivo pre-clinical activity of lead candidate HuMAb antibodies.
• Manages research activities with collaborators on HuMAb projects.
• Performs organic chemistry techniques required for conjugating antibodies to protein and non-protein molecules.
• Compiles manuscripts, posters and oral presentations
• Keeps accurate records of experimental data to standards suitable to support publication, FDA submission, and patent filing. Ensures records of direct reports also meet this standard.
• Analyses experimental data and reports to senior management and research collaborators in a timely fashion.
• Serves as a technical resource to the department and conducts complex troubleshooting. Proposes novel approaches to scientific challenges.
• Oversees organizational aspects of the Product Discovery department such as ordering and equipment repair. Identifies necessary resources for the successful achievement of departmental goals and makes recommendations to senior management.
• Hires, manages and trains staff.  Plans and assigns duties to meet departmental and organizational objectives. Provides guidance and direction to staff; establishing expectations, defining roles, supporting career development and managing performance.
• Performs additional job related duties as required.

REQUIRED QUALIFICATIONS:

• Requires a PhD in life science or related field and a minimum of 4 years of relevant experience. Postdoc experience may be considered relevant experience.
• Prior experience working successfully in a supervisory/management role required.
• Demonstrated success in managing staff performance.  Ability to motivate staff to work effectively and hold staff accountable to individual and departmental goals
• Ability to maintain extensive working knowledge and proficiency in current procedures in molecular and cell biology, biochemistry, and animal modeling.
• Computer literate and proficient in MS Word, Excel and other relevant electronic systems
• Excellent critical thinking, time management and organizational skills. Demonstrated ability to manage and prioritize multiple projects and consistently meet deadlines
• Possesses strong attention to detail, ability to maintain accurate records and excellent proofreading skills.
• Excellent written and verbal communication skills. Ability to communicate effectively with others internally (up, down, and laterally) and externally to the organization