SEARCH CAREER OPPORTUNITIES

Development of ex vivo genome editing approaches for hematopoietic disorders.

The Wolfe laboratory will be filling a postdoctoral position to develop improved genome editing reagents and approaches for sickle cell disease, beta-thalassemia and other hematopoietic disorders with the goal of translating these reagents to clinical trials.  This project will focus on:

1) The development of CRISPR editing reagents with high activity and specificity for ex vivo genome editing in human CD34+ HSPCs.

2) The utilization of unbiased genome-wide techniques for assessing off-target events and other genomic alterations potentially associated with genome editing.

3) The translation of the developed genome editing reagents to clinical application.

These studies will expose the successful candidate to cutting-edge CRISPR/Cas nuclease, base editor and prime editor engineering approaches, and the ex vivo delivery of these reagents to CD34+ HSPCs.  The successful candidate will also learn cutting edge deep-sequencing approaches to evaluate nuclease-based collateral damage to the genome. The successful candidate will have the opportunity to participate in meetings/conferences associated with gene therapy, which will broaden their exposure to cutting edge research within the field. In addition, the successful candidate will learn about Cys₂His₂ zinc finger protein gene regulation technologies that are being developed in the Wolfe laboratory. Candidates should have a Ph.D. in biology, biochemistry, chemistry or a related biomedical science. In addition, the potential candidate must have strong oral and written communication skills and be eager to present research results at national meetings. Prior experience with genome editing systems, cell culture, and deep-sequencing technologies is advantageous, but not required.

Applicants should send a letter (via email) describing their current research activities and their interest in this position, a CV (including publications) and contact information for three references, including your Ph.D. advisor.

Address letters to Scot Wolfe (scot.wolfe@umassmed.edu).

University of Massachusetts Medical School

Department of Molecular, Cell and Cancer Biology

364 Plantation Street, LRB Room 619

Worcester, MA 01605

Further details about the Wolfe laboratory and the positions that are available can be found at https://www.umassmed.edu/Wolfe-Lab/

https://profiles.umassmed.edu/display/133161

UMass Medical School is committed to being an equal opportunity and affirmative action employer and recognizes the power of a diverse community. We encourage applications from protected veterans, individuals with disabilities and those with varied experiences, perspectives and backgrounds to consider UMass Medical School as their employer of choice.