SEARCH CAREER OPPORTUNITIES

Postdoctoral Fellow – Systemic Autoimmunity

Department of Medicine/Rheumatology,

University of Massachusetts Medical School

Responsibilities: 

Design and carry out experiments to explore one or more of the following topics:  molecular mechanisms by which TLR9 negatively regulates T cell activation in murine models of systemic autoimmunity; regulation and gene expression profiles of skin-associated immune cells from cutaneous lupus patients and murine model of cutaneous lupus (Mande P, et al., 2018, JCI) by both high resolution flow cytometry and single cell RNA seq; immune defects of mice that express a gain-of-function (SAVI) mutation.  These projects include collaborations with Drs. John Harris and Kate Fitzgerald.

Expectations also include preparation of oral presentations for program/department research in progress meetings, submission of abstracts for poster and oral presentations at national/international meetings and oversight of technician and/or student working on related projects.

REQUIRED QUALIFICATIONS:

• Highly motivated investigator with a PhD in Immunology, Cell Biology, Molecular Biology or related discipline.
• Working knowledge of cellular immunology, B and T cell development, and innate immune pathways.
• Hands-on laboratory experience in relevant methodologies, trouble-shooting technical problems, and data analysis skills.
• Experience in the following techniques preferred:  handling/injecting/genotyping mice, preparation of lymphoid and dermal/epidermal tissues for histology, isolation and cell culture of lymphocyte populations, multicolor flow cytometry, DNA/RNA purification and quantification, qPCR, enzyme-based immunoassays, and immunofluorescent/confocal microscopy, database comparisons.
• Outstanding organizational and time management skills, as well as the ability to work both independently and as part of a team in a fast-paced environment. 

The position includes opportunities for project and career development, interaction with a diverse, talented and collegial immunology community at UMMS.

To apply for this position:

Find out more about the UMMS research community at http://www.umassmed.edu/research-home/

Send your CV and the contact information for three references to ann.rothstein@umassmed.edu

Please do not apply via this requisition.