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Research Associate IV
Job Number: 2022-42190
Category: Research
Location: Worcester, MA
Shift: Day
Exempt/Non-Exempt: Exempt
Business Unit: UMass Chan Medical School
Department: School - Molecular Cell & Cancer Biology - W495000
Job Type: Full-Time
Salary Grade: 44
Num. Openings: 1
Post Date: Aug. 1, 2023

GENERAL SUMMARY OF POSITION:  

We currently have an opening for a Research Associate to join the laboratory of Dr. Michelle Kelliher at the University of Massachusetts Chan Medical Center. The Kelliher lab studies how leukemia develops using genetically engineered mouse models and patient derived xenografts. We are focused on understanding the molecular and cellular basis of chemoresistance and relapse in an effort to develop novel therapeutic approaches. Our lab uses innovative mouse modeling approaches and single cell sequencing and chromatin accessibility methods to identify features of leukemic stem or initiating cells thought to mediate relapse. This position offers opportunities for career development, including possibly designing and executing independent experiments which could lead to publication.

MAJOR RESPONSIBILITIES:

  • Independently design and perform multiple complex laboratory experiments
  • Identify and utilize all software relevant to experiment and equipment used
  • Interpret data, form conclusions and decide on next steps with a high degree of independence
  • Maintain accurate records, and record results according to established lab, sponsor and University protocol
  • Review literature, publications and grants relevant to assigned projects
  • Record results according to established lab, sponsor & university protocol
  • Perform in-depth data analysis and/or mathematical computations
  • Maintain a detailed lab notebook according to lab practice
  • Compile and analyze data, and present in a format suitable for publication according to PI specifications
  • Present findings at lab/group meetings and other forums
  • Maintain laboratory supply levels and order as noted
  • Manage laboratory equipment service contracts and coordinate maintenance on laboratory equipment.
  • Prepare and label buffers, media, solutions, etc.
  • Monitor and enforce all safety regulation and infection control standards
  • Identify and write standard operation procedures in compliance to EHS regulation specific for the lab
  • Train on IACUC, EHS, Radiation safety protocols
  • Comply with all applicable state, federal university, and sponsor policies and agreements
  • Manage daily operations of the laboratory, including lab personnel, procedures and projects
  • Identify problems and challenges, propose resolutions, implement appropriate solutions
  • Develop and implement new protocols and/or modify defined protocols, as necessary, and with the approval of the PI
  • Prioritize and perform several tasks or procedures simultaneously with attention to detail
  • Perform duties and experiments with independence
  • Mentor and train lab personnel on proper lab conduct and techniques
  • Manage laboratory spending in accordance with budget guidelines provided by PI or designee
  • Assist with budget and/or operational aspects of grant and contract proposals
  • Negotiate with vendors to optimize available resources
  • Contribute independently to writing sections for manuscripts and grants
  • Direct the activities of research support staff
  • Perform other duties as required
  • SUPERVISION RECEIVED:

    Under the direction of the Principal Investigator, or designee

     

    SUPERVISION EXERCISED: 

    Supervise aides, technicians, and associates

    ENVIRONMENTAL WORKING CONDITIONS:

    Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens

 

REQUIRED QUALIFICATIONS:  

  • Bachelors degree in Biological or Natural Science and 5+ years of relevant research experience or a related Masters degree with 3+ years of relevant research experience.
  • Knowledge of Microsoft Office products
  • Strong ability to analyze complex visual data in a quantitative and objective manner
  • Ability to work in a team environmen

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