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R&D Scientist I – Product Discovery
Job Number: 2021-36774Category: Biotechnology
Location: Mattapan, MA
Shift: Day
Exempt/Non-Exempt: Exempt
Business Unit: MassBiologics
Department: MassBiological Labs - MassBiologics of UMMS - W416800
Job Type: Full-Time
Salary Grade: 46
Num. Openings: 1
Post Date: Feb. 10, 2022
POSITION SUMMARY:
R&D Scientist I is responsible for initiating and executing all preclinical scientific research and/or development strategies for monoclonal antibodies. Leads a team to the successful execution of departmental projects and achievement of departmental goals. Investigates the feasibility of applying a wide variety of scientific principles and concepts to potential inventions, products and problems. Plans and executes laboratory research.
ESSENTIAL FUNCTIONS:
- Develops methods for producing antigens required for immunizing HuMAb mice.
- Immunizes mice and screen hybridomas for reactivity with desired antigens.
- Develops and implements in vitro assays to detect and measure biologic activities of all monoclonal antibodies.
- Designs and implements strategies for selection of lead candidate antibodies and antibody conjugates.
- Develops small animal models of disease. Aids in the completion of all in vitro and in vivo pre-clinical activity of lead candidate HuMAb antibodies.
- Coordinates research activities with collaborators on HuMAb projects.
- Performs organic chemistry techniques required for conjugating antibodies to protein and non-protein molecules.
- Assists in compiling manuscripts, posters and oral presentations.
- Keeps accurate records of experimental data to standards suitable to support publication, FDA submission, and patent filing. Ensures records of direct reports also meet this standard.
- Analyzes experimental data and reports to senior management and research collaborators in a timely fashion.
- Serves as a technical resource to the department and conducts moderately complex troubleshooting. Proposes creative problem-solving approaches.
- Takes an active role in the organizational aspects of the Product Discovery department such as ordering and equipment repair.
- Hires, manages and trains staff. Plans and assigns duties to meet departmental and organizational objectives. Provides guidance and direction to staff; establishing expectations, defining roles, supporting career development and managing performance.
- Performs additional job-related duties as required.
REQUIRED QUALIFICATIONS:
- Requires a PhD in life science or related field and a minimum of 2 years of relevant experience or equivalent combination of education and work experience.
- Ability to motivate personnel to work effectively and efficiently
- Demonstrated capability to manage others, assign and schedule work, and conduct performance evaluations
- Ability to maintain extensive working knowledge of current procedures within molecular and cell biology, biochemistry, and animal modeling.
- Computer literate and proficient in MS Word, Excel and other relevant electronic systems
- Excellent problem-solving skills as well as time management and organizational skills. Demonstrated ability to manage and prioritize multiple projects and consistently meet deadlines
- Possesses strong attention to detail, ability to maintain accurate records and excellent proofreading skills
- Must have strong verbal and written communication skills. Ability to communicate effectively with others internally (up, down, and laterally) and externally to the organization
- Ability to work flexible and at times, extended hours to meet business needs
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