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Research Associate III - $2,000 Sign on Bonus!!
Job Number: 2021-36596
Category: Research
Location: Worcester, MA
Shift: Day
Exempt/Non-Exempt: Exempt
Business Unit: UMass Chan Medical School
Department: School - Neurology - W832500
Job Type: Full-Time
Salary Grade: 42
Num. Openings: 1
Post Date: Nov. 20, 2022

GENERAL SUMMARY OF POSITION:  

Dr. Yingleong (Rigel) Chan's laboratory seeks a highly motivated individual with substantial biological mammalian cell culture expertise to perform in-vitro experimentation with human cells. The applicant will be responsible for a wide array of biological assays, including the generation and culture of human-induced pluripotent stem cells (iPSCs), differentiating them into various adult tissue types (microglia, astrocytes, neural progenitors, cerebral organoids, etc.) and performing in-vitro phenotypic assays on them, including viral infection as well as determining various immune phenotypes. Other phenotypes also include cell-death due to exposure to certain drugs or chemicals. Phenotyping is performed mainly using flow cytometry as well as cell sorting using FACS. Depending on the level of expertise and the research interest of the individual, the position allows for developing computational and statistical methods in the context of ongoing projects.

Under the direction of the Principal Investigator or designee, the Research Associate III performs a variety of complex research experiments.

 

 

MAJOR RESPONSIBILITIES:

  • Perform complex laboratory experiments and may be responsible for one or more independent research projects
  • Utilize all software relevant to experiment and equipment used
  • Interpret data, form conclusions and decide on next steps with a significant degree of independence while under the direction of the PI or designee
  • Maintain accurate records, may modify protocols with the approval of the PI or designee
  • Review literature, publications and grants relevant to assigned projects
  • Record results according to established lab, sponsor & university protocol
  • Perform in-depth data analysis and/or mathematical computations
  • Maintain a detailed lab notebook according to lab practice
  • Compile and analyze data, and present in a format suitable for publication according to PI specifications
  • Present findings at lab/group meetings and other forums
  • May oversee laboratory supply levels and order as noted; negotiate with suppliers to optimize available resources
  • Monitor laboratory equipment service contracts and monitor maintenance on laboratory equipment
  • Prepare and label buffers, media, solutions, etc.
  • Assist with and comply with all safety regulation and infection control standards
  • Train on IACUC, IRB, EHS, Radiation safety protocols; may write standard operation procedures in compliance to protocols and specific regulations for the lab
  • Comply with all applicable state, federal university, and sponsor policies and agreements
  • May manage general operations of the laboratory, including lab personnel, procedures and projects
  • Identify problems and challenges, propose resolutions, implement appropriate solutions
  • May create new protocols and/or modify defined protocols, as necessary, and with the approval of the PI
  • Prioritize and perform several tasks or procedures simultaneously with attention to detail
  • Perform duties and experiments with independence
  • Provide training of new lab personnel
  • May monitor laboratory spending in accordance with budgets guidelines provided by PI or designee
  • May assist with budget and/or operational aspects of grant and contract funding
  • May assist with drafting manuscripts sections
  • Perform other duties as required

 

REQUIRED QUALIFICATIONS:  

  • Bachelors degree in Biological or Natural Science and 3+ years of relevant research experience or a related Masters degree with 1 year of relevant research experience.
  • Knowledge of Microsoft Office products
  • Strong ability to analyze complex visual data in a quantitative and objective manner
  • Ability to work in a team environmen

PREFERRED QUALIFICATION:

  • Experience in human cell line culture including culture of induced pluripotent stem cells (iPSCs).
  • Experience in iPSCs to adult tissue type differentiation.
  • Experience in viral infection of human cells.
  • Experience in cell staining and flow cytometry assays.
  • Experience in performing experiments required for next-generation sequencing. Genomic DNA extraction, DNA library prep, etc

SUPERVISION RECEIVED:

Under the direction of the Principal Investigator, or designee

 

SUPERVISION EXERCISED: 

May functionally supervise aides, technicians, and associates

ENVIRONMENTAL WORKING CONDITIONS:

Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens.

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