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Research Associate
Job Number: 2018-32085
Category: Research
Location: Worcester, MA
Shift: Day
Exempt/Non-Exempt: Exempt
Business Unit: UMass Med School
Department: School - Molecular Cell & Cancer Biology - W495000
Salary Grade: 40
Union Code: Non Union Position -W60- Non Unit Professional
Num. Openings: 1
Post Date: Dec. 5, 2018

GENERAL SUMMARY OF POSITION:  

Under the direction of the Principal Investigator or Designee, the Research Associate performs a variety of complex research experiments.

Laboratory uses CRISPR/Cas9 tools for the development of gene therapy reagents.

Additional Major Responsibilities:

  • Participate in the construction and protein purification of Cas9 and Cpf1 nuclease variants with increased precision, and assays for their activity in mammalian cells.
  • Maintain the laboratory database and frozen archive of plasmids and bacterial strains.
  • Prepare competent bacterial cells for transformation and media reagents.
  • Ordering standard supplies for the laboratory.

 

MAJOR RESPONSIBILITIES:

  • Conducts in-depth analysis of research experiments
  • Performs complex laboratory experiments
  • Interprets data, forms conclusion, and decides on and plans next experiments to be done with a high degree of independence
  • Compiles and analyzes data and performs computations using image analysis software, spreadsheets, graphing, and curve fitting software
  • May modify protocols and be responsible for a single, independent research project
  • Assists in writing the text of scientific publications and grants.  Reviews literature
  • Trains new laboratory personnel, students, and collaborators
  • Maintains laboratory supplies and equipment
  • Complies with all safety and infection control standards
  • Perform other duties as required.

REQUIRED QUALIFICATIONS:  

  • Bachelor’s degree in Biological Sciences, or equivalent experience
  • 1 year relevant research experience
  • Knowledge of Microsoft Office products
  • Strong ability to analyze complex visual data in a quantitative and objective manner
  • Judgment and action skills required to solve commonly encountered problems

PREFERRED QUALIFICATIONS:

  • FPLC-based protein purification experience -required
  • Mammalian Cell culture experience
  • Basic molecular biology techniques (PCR, Restriction Enzyme mediated cloning, Gel electrophoresis, Qiagen DNA miniprep)
  • Bacteria Strain preparation and handling (competent cell preparation and agar plate preparation).

SUPERVISION RECEIVED:

Under the direction of the Principal Investigator, or designee

 

SUPERVISION EXERCISED: 

May functionally supervise Lab Technicians and Aides

ENVIRONMENTAL WORKING CONDITIONS:

Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens. 

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