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Research Associate I
Job Number: 2018-32087
Category: Research
Location: Worcester, MA
Shift: Day
Exempt/Non-Exempt: Exempt
Business Unit: UMass Med School
Department: School - Molecular Cell & Cancer Biology - W495000
Salary Grade: 42
Num. Openings: 1
Post Date: Dec. 19, 2018

GENERAL SUMMARY OF POSITION:  

Under the direction of the Principal Investigator or designee, the Research Associate I performs a variety of complex research experiments.

 

Laboratory uses CRISPR/Cas9 tools for the development of gene therapy reagents.

Additional Major Responsibilities:

  • Participate in the construction and protein purification of Cas9 and Cpf1 nuclease variants with increased precision, and assays for their activity in mammalian cells.
  • Maintain the laboratory database and frozen archive of plasmids and bacterial strains.
  • Prepare competent bacterial cells for transformation and media reagents.
  • Ordering standard supplies for the laboratory.

MAJOR RESPONSIBILITIES:

  • Perform complex laboratory experiments
  • Conduct in-depth analysis of research experiments
  • Interpret data, form conclusions, and decide on and plan the next experiments to be done with a high degree of independence
  • Write standard operating procedures, schedule work, analyze data, maintain accurate records, and write reports
  • Compile and analyze data. Perform computations using image analysis software, spreadsheets, graphing, and curve fitting software
  • May modify protocols and be responsible for a single, independent research project
  • May assist with budget and/or operational aspects of grant and contract proposals
  • Assist in writing the text of scientific publications and grants.  Review literature
  • Train new laboratory personnel, students, and collaborators
  • Comply with all safety and infection control standards
  • Perform other duties as required.

                                                                                                           

 

REQUIRED QUALIFICATIONS:  

  • Bachelor’s degree in the Biological Sciences, or equivalent experience
  • 3 years of relevant research experience
  • Knowledge of Microsoft Office products
  • Strong ability to analyze complex visual data in a quantitative and objective manner
  • Judgment and action skills required to solve commonly encountered problems

PREFERRED QUALIFICATIONS:

  • FPLC-based protein purification experience -required
  • Mammalian Cell culture experience
  • Basic molecular biology techniques (PCR, Restriction Enzyme mediated cloning, Gel electrophoresis, Qiagen DNA miniprep)
  • Bacteria Strain preparation and handling (competent cell preparation and agar plate preparation).

SUPERVISION RECEIVED:

Under the direction of the Principal Investigator, or designee

 

SUPERVISION EXERCISED: 

May functionally supervise aides, technicians, and associates

ENVIRONMENTAL WORKING CONDITIONS:

Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens.

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