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Location: Worcester, MA
Business Unit: UMass Med School
Department: School - Biochemistry & Molecular Pharm - W404000
Salary Grade: 40
Union Code: Non Union Position -W60- Non Unit Professional
Num. Openings: 1
Post Date: June 22, 2018
GENERAL SUMMARY OF POSITION:
Positions are available in the Miller laboratory to extend the scope of bioluminescence for non-invasive imaging of specific biological processes and disease states in live cells and animals. Work in the lab is inherently multi-disciplinary and may include protein engineering, mouse imaging, culture of multiple cell lines, vector design, enzyme assays, chemical synthesis, and immunohistochemistry of tissues. Examples of recent lab efforts include bioluminescence imaging of gene expression and enzymatic activity in the brain [Nature Methods 11, 393 (2014); JACS 137, 8684 (2015); Angewandte Chemie 55, 4943 (2016)], detection of latent luciferase activity in fruit flies [PNAS 111, 4443 (2014); ACS Chem Bio 12, 2946 (2017)], and the development of new selective mutant luciferases and synthetic luciferin substrates [JACS 136, 13277 (2014); Angewandte Chemie 55, 4943 (2016); Org Lett 19, 5836 (2017)]. Motivated and inherently curious critical thinkers with experience in molecular biology, cell biology, biochemistry, chemical biology, neuroscience, and/or animal studies are particularly encouraged to apply.
Under the direction of the Principal Investigator or Designee, the Research Associate performs a variety of complex research experiments.
- Conducts in-depth analysis of research experiments
- Performs complex laboratory experiments
- Interprets data, forms conclusion, and decides on and plans next experiments to be done with a high degree of independence
- Compiles and analyzes data and performs computations using image analysis software, spreadsheets, graphing, and curve fitting software
- May modify protocols and be responsible for a single, independent research project
- Assists in writing the text of scientific publications and grants. Reviews literature
- Trains new laboratory personnel, students, and collaborators
- Maintains laboratory supplies and equipment
- Complies with all safety and infection control standards
- Perform other duties as required.
- Bachelor’s degree in Biological Sciences, or equivalent experience
- 1 year relevant research experience
- Knowledge of Microsoft Office products
- Strong ability to analyze complex visual data in a quantitative and objective manner
- Judgment and action skills required to solve commonly encountered problems
- Applicants must have (or expect to obtain shortly) a degree in Biochemistry, Cell Biology, Genetics, Molecular Biology, Chemical Biology, Neuroscience, or related fields.
- Applicants should have experience in several of the following areas: molecular cloning, PCR, protein expression, mutagenesis, protein engineering, cell culture, mouse husbandry, disease models, imaging, immunohistochemistry, biochemistry.
Under the direction of the Principal Investigator, or designee
May functionally supervise Lab Technicians and Aides
ENVIRONMENTAL WORKING CONDITIONS:
Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens.
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